P-224: Mechanisms That Reduce Endometrial Receptivity in Endometriosis

Background: Several studies indicate clear relationship between infertility and endometriosis. However, the etiology of this association is uncertain. Endometrial dysfunction is a possible cause of infertility in women with endometriosis, which could explain the high rates of implantation failure and miscarriages in these women. Delay in endometrial maturation and intrauterine biochemical abnormalities may be causing this problem. Materials and Methods: Review study Results: It has been shown that in patients with endometriosis, during implantation window, express of the ligands that mediated embryo- endometrium attachment (like α5β integrin), are low. On the other hand, in the many of these cases, the production of enzymes involved in the synthesis of the ligands for L-Selectin (the protein that coats the trophoblasts in the maternal blood level) are lower than the control group. It seems that the presence of ectopic endometrium and its secreted inflammatory mediators can reduce endometrial reception, directly and indirectly. For example, secretion of specific types of prostaglandin by the peritoneal endometrium, indeed of inhibition of the binding of trophoblasts to their endometrial receptors, can also induce uterine contractions, that excrete embryo. Conclusion: In this paper, the mechanisms involved in reducing endometrial receptivity in the women with endometriosis, will be reviewed.